Knowing what people are exposed to, by how much, when, and where it comes from is the centerpiece of exposure science. Only when the sources of exposure are accurately determined, we can protect public health by reducing exposure. The role of the occupational and environmental health professionals is to identify these potential hazards, evaluate the risk they pose to public and to recommend control measures which can manage the risks involved. Among environmental exposure, indoor is critical as people spend as much as 90% of their daily life and indoor concentrations are often higher than outdoors. Understanding and control of indoor environmental quality requires multidisciplinary approaches, as it is affected by pollution source, ventilation, transportation and occupants.

Our research interests span the exposure-disease continuum. Specifically, we are developing or measuring biomarkers to estimate the internal dose and preclinical effects in human and animal models; analyzing exposure and health outcomes via biomarkers and constructing models statistically and toxicokinetically. In order to do so, we have been collecting human tissues exposed to environmental hazards (e.g. chemicals or air pollutants), determining the biomarkers of exposure and effects, and analyzing statistical models. We also resort to animal model such as multi-panel of mouse inbred strains, toxicokinetics (TK) /toxicodynamics (TD), and omics approaches (e.g. transcriptomics and metabolomics) to acquire valid information applicable to human populations.